Most cases of serotonin syndrome are mild and may be treated by withdrawal of the offending agent and supportive care. Diagnosis is made using the Hunter Serotonin Toxicity Criteria, which require the presence of one of the following classical features or groups of features: spontaneous clonus inducible clonus with agitation or diaphoresis ocular clonus with agitation or diaphoresis tremor and hyperreflexia or hypertonia, temperature above 100.4° F (38° C), and ocular or inducible clonus. ![]() Most reported cases of serotonin syndrome are in patients using multiple serotonergic drugs or who have had considerable exposure to a single serotonin-augmenting drug. It is characterized by mental status changes, autonomic instability, and neuromuscular hyperactivity. Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonergic activity in the nervous system.
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